Okay, so there's two big things to talk about with these kinds of enemies:
Kinds
Prototyping
I'm really avoiding prototyping as long as I can, so I will only discuss it as far as which kinds can be prototyped or not.
In Sburb's lands there are five common enemies: Imps, Ogres, Basilisks, Giclopses, and Liches. There are also Denizens, who seem to have personal minions (Grandpa Harley's trophy).
Now, the first question I have is, are five enemies enough? If not, what else do we add? Further, how are these five enemies different? Is it just raw power? I would like to answer no to the first question. If nothing else I would like a particular kind of sea-going enemy who is vastly powerful and capable of destroying just-entered players who think "Screw the gates, Imma gonna swim!" However, that doesn't address common enemies. What else is there? How do we handle this? Thoughts, please?
EDIT: All of the common enemies should be affected by prototypings, obviously.
Now, Denizens seem to be somewhat personalized but obviously we can't personalize a new Denizen for every player. We should instead make four or five Denizens per domain and give them each minions who look similar but are smaller. Denizens obviously stay asleep until late in the game, but they apparently can be woken early, or at least are guarded heavily, to account for John's death. I would also like to propose that Denizens cannot be affected (at least very much) by players they are not directly opposing. These guys are the individual challenges; BQ and BK are the group effort.
As for minions, they are probably just the enemies inside a palace, replacing Underlings. But maybe they do other things too. Not sure. We should brainstorm.
EDIT: These enemies, if the Typheus Minion is any indication, are not in fact affected by prototypings. Perhaps they have powers based on the Domain they have taken control of? Or maybe we should just stick to prototypings.